> Intro: Drosophila NSCs in the central brain (CB) and thoracic ventral nerve cord (VNC) enter into quiescence at the end of embryogenesis, and subsequently exit quiescence (reactivate) in response to dietary amino acids, typically within 24 h after larval hatching (h ALH) (Fig. 1a) [14,15,16]. The nutritional signals originate from the Drosophila fat body—functional equivalent of mammalian liver and adipose tissue [17]—and lead to activation of the insulin/insulin-like growth factor (IGF) signaling pathway [18,19] and inactivation of the Hippo signaling pathway in NSCs for their reactivation [18,19,20,21].
"SUMOylation of Warts kinase promotes neural stem cell reactivation" (2024) https://www.nature.com/articles/s41467-024-52569-y :
> Intro: Drosophila NSCs in the central brain (CB) and thoracic ventral nerve cord (VNC) enter into quiescence at the end of embryogenesis, and subsequently exit quiescence (reactivate) in response to dietary amino acids, typically within 24 h after larval hatching (h ALH) (Fig. 1a) [14,15,16]. The nutritional signals originate from the Drosophila fat body—functional equivalent of mammalian liver and adipose tissue [17]—and lead to activation of the insulin/insulin-like growth factor (IGF) signaling pathway [18,19] and inactivation of the Hippo signaling pathway in NSCs for their reactivation [18,19,20,21].