pazimzadeh 1 day ago

Seems par for the course since our adaptive immune system is based on an old viral/transposon recombinase.

Transposon Molecular Domestication and the Evolution of the RAG Recombinase

https://pmc.ncbi.nlm.nih.gov/articles/PMC6494689/

Here is the actual study:

Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates

https://www.science.org/doi/10.1126/science.aeh3441

  • shevy-java 1 day ago

    Is VDJ recombination based on viruses or transposons?

    It's the first time I hear this. Can't yet say much about it until I can verify that.

    • pazimzadeh 21 hours ago

      Yes, the RAG transposon inserted itself into a variable domain exon about 500 million years ago. Here’s a more recent paper on this:

      Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon

      https://pubmed.ncbi.nlm.nih.gov/40614193/

      > It's the first time I hear this. Can't yet say much about it until I can verify that.

      How are you going to verify it?

readthenotes1 1 day ago

This must be microbe awareness day.

Earlier iirc someone posted

https://www.cbc.ca/news/health/cancer-infections-9.7361622

  • pxc 1 day ago

    I thought viruses weren't considered to be microbes. Was I mistaken? Is there a broader category that includes things like bacteria and also viruses?

    • titanomachy 23 hours ago

      In the context of "things that cause diseases", "pathogen" covers both. But that isn't exactly an answer to your question.

odmcownckexnn 1 day ago

Can we please start banning articles with paywalls from being posted at all?

If I cannot read without a subscription (or a damn paywall removed), it shouldn’t be posted here. This is tantamount to posting an ad for an NYT sub.

  • creatonez 1 day ago

    The HN rules are that paywalled content can be posted only if it's trivially bypassable via a free tool. The NYTimes links work on fresh IP addresses as part of a free allowance for new readers, which is why the proxy-based archive website archive.today is able to get through. I'm not a big fan of this being allowed, but there is some thought to it at least, they aren't just allowing anything.

    • ectospheno 1 day ago

      It is a shame that the free tool of choice is a site that put a DDOS attack in its captcha. So my options are not read the article or... not read the article. Nice.

      • gpm 1 day ago

        You say that like "commit a felony to read the article" isn't a valid option (/s).

    • ojihgfhoniyfc 1 day ago

      That’d be sensible reasoning IF the articles were already posted with a paywall-free url, but they are not, so as it stands these are essentially just ads.

      • creatonez 1 day ago

        IIRC the staff will usually intentionally elevate bypass links to the top whenever they see them posted in the comments. (And when a link has already been posted they tend to sink comments like yours that complain without providing a link, lol)

        • kdkdkdkwkd 1 day ago

          Again, why not require the bypassed link right from the gate, then? You’d sidestep people complaining about it and wouldn’t little the comment section with people posting alternative links or asking for them.

          NYT is the only one profiting getting free publicity for their subscription service here.

          • Aquitard 1 day ago

            Did you create three accounts just to reply? And if so why not stick to just one?

          • gumby 1 day ago

            I speculated in a different reply that it’s to reduce dups. Two people could post the same article, but if they used different paywall-bypassers they would appear as separate submissions.

            • _ifton 2 hours ago

              Link the original article with a paywall flag. If paywall, require paywall-bypasser, and link both articles to submission.

      • gumby 1 day ago

        My understanding is you’re not supposed to post paywall-cutting links but it’s ok to post them as comments. Perhaps to prevent dupes? Or perhaps there is no such rule.

        • jasomill 9 hours ago

          People do it all the time for LWN. NYT offers subscribers a similar ability to generate free links to paywalled content.

          FYI, many US public libraries offer free access to NYT subscription content (which can be used to generate free links).

  • Terr_ 23 hours ago

    IMO a good approach would be to surface the status of links to readers, with an icon for "pay-walled" or "register-walled", then see how organic voting affects things.

    • tedd4u 22 hours ago

      I like that idea but aren't we supposed to read the article before voting?

      • Terr_ 18 hours ago

        So if I posted a link to something nobody can actually read, does that mean all downvotes are unfair violations if the social contract?

        Availability is itself a meaningful feature for curating the feed.

        Sometimes the comment section rescues things, other times it's a decision between two competing submissions, where—all else being equal—the accessible version ought to win.

  • Mistletoe 23 hours ago

    I’m just always amazed that this many HN readers pay for the NY Times or any of the other publications constantly posted here with paywalls.

  • metalman 22 hours ago

    while that would be nice, generaly there are many knowledgeable comments several pay grades abovethe nyt staff, here in the comments, which if you wait for them to build and then do a page search for your terms of interest, can often take you painlessly to a susinct synopsis of the issues under discussion

  • baranul 9 hours ago

    Probably the problem is ignored because of well known archive sites that circumvent the subscription issue. But, I do agree with the suggestion of marking posts as paywalled, to give people more choice on whether to open them.

theflyingelvis 9 hours ago

Looking forward to the alex jones take on this /s

shevy-java 1 day ago

There was no theft involved. "Genes" are not "owned".

  • AnimalMuppet 1 day ago

    If the virus didn't evolve the gene on its own, then "stole" seems like a fair description of how it got it.

    • wormius 23 hours ago

      You wouldn't download a gene, would you?

      • Mistletoe 23 hours ago

        I’d actually love to, can I swap out many of mine with LeBron and Albert Einstein? Anyone got the torrent link?

    • bell-cot 21 hours ago

      I suspect the original author's copyright had expired, so the gene was public domain.